Pub. Date : 2022 Apr
PMID : 35157847
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Deglutarylation of glutaryl-CoA dehydrogenase by deacylating enzyme SIRT5 promotes lysine oxidation in mice. | Lysine | glutaryl-Coenzyme A dehydrogenase | Mus musculus |
| 2 | Here, we identify glutarylation on the lysine oxidation pathway enzyme glutaryl-CoA dehydrogenase (GCDH) and show increased GCDH glutarylation when glutaryl-CoA production is stimulated by lysine catabolism. | Lysine | glutaryl-Coenzyme A dehydrogenase | Mus musculus |
| 3 | Here, we identify glutarylation on the lysine oxidation pathway enzyme glutaryl-CoA dehydrogenase (GCDH) and show increased GCDH glutarylation when glutaryl-CoA production is stimulated by lysine catabolism. | Lysine | glutaryl-Coenzyme A dehydrogenase | Mus musculus |
| 4 | Here, we identify glutarylation on the lysine oxidation pathway enzyme glutaryl-CoA dehydrogenase (GCDH) and show increased GCDH glutarylation when glutaryl-CoA production is stimulated by lysine catabolism. | Lysine | glutaryl-Coenzyme A dehydrogenase | Mus musculus |
| 5 | Here, we identify glutarylation on the lysine oxidation pathway enzyme glutaryl-CoA dehydrogenase (GCDH) and show increased GCDH glutarylation when glutaryl-CoA production is stimulated by lysine catabolism. | Lysine | glutaryl-Coenzyme A dehydrogenase | Mus musculus |
| 6 | Here, we identify glutarylation on the lysine oxidation pathway enzyme glutaryl-CoA dehydrogenase (GCDH) and show increased GCDH glutarylation when glutaryl-CoA production is stimulated by lysine catabolism. | Lysine | glutaryl-Coenzyme A dehydrogenase | Mus musculus |
| 7 | Our data reveal that glutarylation of GCDH impacts its function, ultimately decreasing lysine oxidation. | Lysine | glutaryl-Coenzyme A dehydrogenase | Mus musculus |
| 8 | Together, these data support a feedback loop model within the lysine/tryptophan oxidation pathway in which glutaryl-CoA is produced, in turn inhibiting GCDH function via glutaryl modification of GCDH lysine residues, and can be relieved by SIRT5 deacylation activity. | Lysine | glutaryl-Coenzyme A dehydrogenase | Mus musculus |
| 9 | Together, these data support a feedback loop model within the lysine/tryptophan oxidation pathway in which glutaryl-CoA is produced, in turn inhibiting GCDH function via glutaryl modification of GCDH lysine residues, and can be relieved by SIRT5 deacylation activity. | Lysine | glutaryl-Coenzyme A dehydrogenase | Mus musculus |