Title : ABT199/venetoclax potentiates the cytotoxicity of alkylating agents and fludarabine in acute myeloid leukemia cells.

Pub. Date : 2022

PMID : 35154579






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 ABT199/venetocalx upregulated anti-apoptotic MCL1 as a compensatory mechanism but addition of (Bu+4HC) or (Bu+Flu) negated this effect by CASPASE 3-mediated cleavage of MEK1/2 and its substrate MCL1. Busulfan caspase 3 Homo sapiens