Pub. Date : 2022 May
PMID : 35149777
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | UGT1A1 genetic variants are associated with increases in bilirubin levels in rheumatoid arthritis patients treated with sarilumab. | Bilirubin | UDP glucuronosyltransferase family 1 member A1 | Homo sapiens |
| 2 | Variants in the UGT1A1 gene were strongly associated with maximum bilirubin elevations in sarilumab-treated patients (rs4148325; p = 2.88 x 10-41) but were not associated with aminotransferase elevations. | Bilirubin | UDP glucuronosyltransferase family 1 member A1 | Homo sapiens |
| 3 | These findings suggest that most bilirubin increases during sarilumab treatment are related to genetic variation in UGT1A1 rather than underlying liver injury. | Bilirubin | UDP glucuronosyltransferase family 1 member A1 | Homo sapiens |