Pub. Date : 2022
PMID : 35126812
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Zingerone Inhibits the Neutrophil Extracellular Trap Formation and Protects against Sepsis via Nrf2-Mediated ROS Inhibition. | Reactive Oxygen Species | nuclear factor, erythroid derived 2, like 2 | Mus musculus |
| 2 | Furthermore, inhibition of nuclear factor erythroid 2-related factor 2 (Nrf2) with its specific antagonist significantly counteracted the suppressive effects of zingerone on ROS and NETs and retarded the protective role of zingerone against sepsis-associated organ injury. | Reactive Oxygen Species | nuclear factor, erythroid derived 2, like 2 | Mus musculus |
| 3 | Furthermore, inhibition of nuclear factor erythroid 2-related factor 2 (Nrf2) with its specific antagonist significantly counteracted the suppressive effects of zingerone on ROS and NETs and retarded the protective role of zingerone against sepsis-associated organ injury. | Reactive Oxygen Species | nuclear factor, erythroid derived 2, like 2 | Mus musculus |
| 4 | Above all, our results indicate that zingerone treatment obviously attenuates NET formation and inflammatory response via Nrf2-mediated ROS inhibition, thus providing a novel therapeutic strategy against sepsis-induced injury. | Reactive Oxygen Species | nuclear factor, erythroid derived 2, like 2 | Mus musculus |