Pub. Date : 2022 Mar
PMID : 35124344
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Further, the study also analyzed the regulatory role of NLRP3 in resistance to gemcitabine among ovarian cancer cells and its underlying interaction mechanisms with Wnt/beta-catenin in vitro. | gemcitabine | NLR family pyrin domain containing 3 | Homo sapiens |
| 2 | The current in vitro study detailed that when downregulating NLRP3, it could enhance the gemcitabine sensitivity in GRC cells. | gemcitabine | NLR family pyrin domain containing 3 | Homo sapiens |
| 3 | In case of gemcitabine-resistant cells, the up-regulation of NLRP3 can increase the drug-resistance through the activation of IL-1beta, EMT and Wnt/beta-catenin signaling pathways. | gemcitabine | NLR family pyrin domain containing 3 | Homo sapiens |
| 4 | The current study conducted in vitro experiments and the findings infer that the downregulation of NLRP3 can enhance the sensitivity of gemcitabine among GRC cells. | gemcitabine | NLR family pyrin domain containing 3 | Homo sapiens |