Pub. Date : 2022 Feb
PMID : 35123623
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | METHODS: CCK-8 method was used to detect the viability of MM cell lines H929 and ARP-1 treated by different concentrations of celastrol, bortezomib, and their combination, and the synergistic effect was determined by Kim"s formula. | celastrol | actin related protein 1A | Homo sapiens |
| 2 | RESULTS: Celastrol could significantly inhibit the proliferation of H929 and ARP-1 cells (r=0.9018, r=0.9244) and induce apoptosis in a time-dependent manner. | celastrol | actin related protein 1A | Homo sapiens |
| 3 | Compared with the control group, celastrol could significantly up-regulate the expression of PARP and cleaved caspase-3 while down-regulate the expression of p-IRAK4, p-ERK, and p-p38 in H929 and ARP-1 cells. | celastrol | actin related protein 1A | Homo sapiens |
| 4 | Celastrol and bortezomib alone inhibited the proliferation of H929 and ARP-1 cells. | celastrol | actin related protein 1A | Homo sapiens |
| 5 | CONCLUSION: Celastrol can inhibit the proliferation and promote the apoptosis of H929 and ARP-1 cells, which may be related to inhibiting the phosphorylation of IRAK4 and blocking the activation of IRAK4/ERK/p38 signaling pathway. | celastrol | actin related protein 1A | Homo sapiens |
| 6 | Celastrol combined with bortezomib has synergistic effect, which can more effectively inhibit the proliferation and induce apoptosis of H929 and ARP-1 cells. | celastrol | actin related protein 1A | Homo sapiens |