Pub. Date : 2022 Jan 29
PMID : 35123263
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | The function of SARS-CoV-2 spike protein is impaired by disulfide-bond disruption with mutation at cysteine-488 and by thiol-reactive N-acetyl-cysteine and glutathione. | Sulfhydryl Compounds | surface glycoprotein | Severe acute respiratory syndrome coronavirus 2 |
2 | Consistently, in vitro binding of RBD and ACE2, spike-mediated cell-cell fusion, and pseudotyped viral infection of VeroE6/TMPRSS2 cells were inhibited by the thiol-reactive compounds N-acetylcysteine (NAC) and a reduced form of glutathione (GSH). | Sulfhydryl Compounds | surface glycoprotein | Severe acute respiratory syndrome coronavirus 2 |