Pub. Date : 2022 Apr 6
PMID : 35121110
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | While the high-dose testosterone (high-T) treatment is currently being tested in clinical trials of castration-resistant prostate cancer (CRPC), there is still a pressing need to fully understand the underlying mechanism and thus develop treatment strategies to exploit this tumor-suppressive activity of AR. | Testosterone | androgen receptor | Homo sapiens |
| 2 | In this study, we demonstrate that retinoblastoma (Rb) family proteins play a central role in maintaining the global chromatin binding and transcriptional repression program of AR, and that Rb inactivation desensitizes CRPC to the high-dose testosterone treatment in vitro and in vivo. | Testosterone | androgen receptor | Homo sapiens |