Pub. Date : 2022 Feb 3
PMID : 35115509
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The anthelmintic drug niclosamide induces GSK-beta-mediated beta-catenin degradation to potentiate gemcitabine activity, reduce immune evasion ability and suppress pancreatic cancer progression. | Niclosamide | catenin (cadherin associated protein), beta 1 | Mus musculus |
| 2 | Mechanistically, niclosamide exerted these therapeutic effects via targeting beta-catenin. | Niclosamide | catenin (cadherin associated protein), beta 1 | Mus musculus |
| 3 | Moreover, niclosamide induced beta-catenin phosphorylation and protein degradation. | Niclosamide | catenin (cadherin associated protein), beta 1 | Mus musculus |
| 4 | Interestingly, niclosamide also induced GSK-3beta phosphorylation, which is involved in the ubiquitination degradation of beta-catenin. | Niclosamide | catenin (cadherin associated protein), beta 1 | Mus musculus |
| 5 | Pharmacological activation of beta-catenin by methyl vanillate and beta-catenin overexpression abolished the inhibitory effects of niclosamide. | Niclosamide | catenin (cadherin associated protein), beta 1 | Mus musculus |
| 6 | Pharmacological activation of beta-catenin by methyl vanillate and beta-catenin overexpression abolished the inhibitory effects of niclosamide. | Niclosamide | catenin (cadherin associated protein), beta 1 | Mus musculus |
| 7 | Thus, our study indicated that niclosamide induces GSK-beta-mediated beta-catenin degradation to potentiate gemcitabine activity, reduce immune evasion ability, and suppress pancreatic cancer progression. | Niclosamide | catenin (cadherin associated protein), beta 1 | Mus musculus |