Title : Esterification promotes the intracellular accumulation of roxadustat, an activator of hypoxia-inducible factors, to extend its effective duration.

Pub. Date : 2022 Mar

PMID : 35114188






3 Functional Relationships(s)
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1 In the kidneys and livers of mice, both of which are unique sites of EPO production, a majority of the methyl-esterified roxadustat was deesterified within 6 hours after drug administration. roxadustat erythropoietin Mus musculus
2 Additionally, we confirmed that methyl-esterified roxadustat activated erythropoiesis in mice by inducing EPO mRNA expression exclusively in renal interstitial cells, which have intrinsic EPO-producing potential. roxadustat erythropoietin Mus musculus
3 Additionally, we confirmed that methyl-esterified roxadustat activated erythropoiesis in mice by inducing EPO mRNA expression exclusively in renal interstitial cells, which have intrinsic EPO-producing potential. roxadustat erythropoietin Mus musculus