Pub. Date : 2022
PMID : 35111269
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The Natural Compound Dehydrocrenatidine Attenuates Nicotine-Induced Stemness and Epithelial-Mesenchymal Transition in Hepatocellular Carcinoma by Regulating a7nAChR-Jak2 Signaling Pathways. | Nicotine | Janus kinase 2 | Homo sapiens |
| 2 | Result: We found that nicotine exposure stimulated the HCC tumorigenicity by inducing the expression of one of the key nAChRs subunit that is alpha7nAChR as well as the expression of Janus kinase (JAK)-2. | Nicotine | Janus kinase 2 | Homo sapiens |
| 3 | Thus, these findings suggest the nicotine effect on HCC progression via alpha7nAChR-mediated JAK2 signaling pathways, and DHCT treatment enhances the therapeutic potential of HCC patients via overcoming/reversing the effect of nicotine in HCC patients. | Nicotine | Janus kinase 2 | Homo sapiens |