Title : 3β-Hydroxysteroid dehydrogenase expressed by gut microbes degrades testosterone and is linked to depression in males.

Pub. Date : 2022 Mar 9

PMID : 35108497






2 Functional Relationships(s)
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1 Introducing 3beta-HSD into Escherichia coli enhanced its ability to degrade testosterone. Testosterone hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens
2 These results suggest that 3beta-HSD expressed by gut microbes may be associated with depressive symptoms due to testosterone degradation. Testosterone hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 Homo sapiens