Title : An early Shh-H2O2 reciprocal regulatory interaction controls the regenerative program during zebrafish fin regeneration.

Pub. Date : 2022 Mar 15

PMID : 35107164






4 Functional Relationships(s)
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1 An early Shh-H2O2 reciprocal regulatory interaction controls the regenerative program during zebrafish fin regeneration. Hydrogen Peroxide sonic hedgehog signaling molecule a Danio rerio
2 We demonstrate that H2O2 controls Shh expression and that Shh in turn regulates the H2O2 level via a canonical pathway. Hydrogen Peroxide sonic hedgehog signaling molecule a Danio rerio
3 We demonstrate that H2O2 controls Shh expression and that Shh in turn regulates the H2O2 level via a canonical pathway. Hydrogen Peroxide sonic hedgehog signaling molecule a Danio rerio
4 These data support the existence of an early positive crosstalk between Shh and H2O2 that might be more generally involved in various processes paving the way to improve regenerative processes, particularly in vertebrates. Hydrogen Peroxide sonic hedgehog signaling molecule a Danio rerio