Title : The P300 acetyltransferase inhibitor C646 promotes membrane translocation of insulin receptor protein substrate and interaction with the insulin receptor.

Pub. Date : 2022 Mar

PMID : 35074429






3 Functional Relationships(s)
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1 Inhibition of P300 acetyltransferase activity by C646 drastically increased tyrosine phosphorylation of the insulin receptor protein substrates (IRS1/2) without affecting the tyrosine phosphorylation of the beta subunit of the insulin receptor (IRbeta) in hepatocytes in the absence of insulin. Tyrosine insulin receptor substrate 1 Homo sapiens
2 Intriguingly, we demonstrate that C646 activates IRbeta"s tyrosine kinase activity and directly promotes IRbeta interaction with IRS1/2, leading to the tyrosine phosphorylation of IRS1/2 and subsequent activation of insulin signaling even in the absence of insulin. Tyrosine insulin receptor substrate 1 Homo sapiens
3 Intriguingly, we demonstrate that C646 activates IRbeta"s tyrosine kinase activity and directly promotes IRbeta interaction with IRS1/2, leading to the tyrosine phosphorylation of IRS1/2 and subsequent activation of insulin signaling even in the absence of insulin. Tyrosine insulin receptor substrate 1 Homo sapiens