Pub. Date : 2021
PMID : 35069210
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Dapagliflozin Alleviates Renal Fibrosis by Inhibiting RIP1-RIP3-MLKL-Mediated Necroinflammation in Unilateral Ureteral Obstruction. | dapagliflozin | mixed lineage kinase domain like pseudokinase | Rattus norvegicus |
| 2 | In H2O2-treated HK-2 cells, dapagliflozin and RIP inhibitors suppressed overexpression of RIP1-RIP3-MLKL proteins and pyroptosis-related cytokines, decreased intracellular reactive oxygen species production and apoptotic cell death, whereas cell viability was improved. | dapagliflozin | mixed lineage kinase domain like pseudokinase | Rattus norvegicus |
| 3 | Our findings suggest that dapagliflozin ameliorates renal fibrosis by inhibiting RIP1-RIP3-MLKL-mediated necroinflammation via Wnt3alpha/beta-catenin/GSK-3beta signaling in UUO. | dapagliflozin | mixed lineage kinase domain like pseudokinase | Rattus norvegicus |