Pub. Date : 2022 Mar
PMID : 35063506
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Prostate secretory protein 94 (PSP94) inhibits sterol-binding and export by the mammalian CAP protein CRISP2 in a calcium-sensitive manner. | Sterols | cysteine rich secretory protein 2 | Homo sapiens |
| 2 | This sterol-binding and export function of yeast Pry proteins is conserved in the mammalian CRISP proteins and other CAP superfamily members. | Sterols | cysteine rich secretory protein 2 | Homo sapiens |
| 3 | In addition, mutations that affect the formation of the PSP94-CRISP2 heteromeric complex restore sterol binding. | Sterols | cysteine rich secretory protein 2 | Homo sapiens |
| 4 | The observation that PSP94 modulates the sterol-binding function of CRISP2 in a calcium-dependent manner has potential implications for the role of PSP94 and CRISP2 in prostate physiology and progression of prostate cancer. | Sterols | cysteine rich secretory protein 2 | Homo sapiens |