Title : Mechanistic Insights into Pyridine Ring Degradation Catalyzed by 2,5-Dihydroxypyridine Dioxygenase NicX.

Pub. Date : 2022 Feb 7

PMID : 35060702






3 Functional Relationships(s)
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1 2,5-Dihydroxypyridine dioxygenase (NicX) from Pseudomonas putida KT2440 is a mononuclear non-heme iron oxygenase that can catalyze the oxidative pyridine ring cleavage. pyridine 2,5-dihydroxypyridine 5,6-dioxygenase Pseudomonas putida KT2440
2 The NicX-catalyzed pyridine ring degradation contains three parts, including the attack of Fe(II)-superoxo on the activated pyridine ring, the dissociation of the Op-Od bond, and the ring-opening of the seven-membered-ring lactone. pyridine 2,5-dihydroxypyridine 5,6-dioxygenase Pseudomonas putida KT2440
3 The NicX-catalyzed pyridine ring degradation contains three parts, including the attack of Fe(II)-superoxo on the activated pyridine ring, the dissociation of the Op-Od bond, and the ring-opening of the seven-membered-ring lactone. pyridine 2,5-dihydroxypyridine 5,6-dioxygenase Pseudomonas putida KT2440