Title : Molecular imaging of Neuroendocrine Prostate Cancer by targeting Delta-like Ligand 3.

Pub. Date : 2022 Jan 20

PMID : 35058323






3 Functional Relationships(s)
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1 Using the zirconium-89 (89Zr)-labeled DLL3 targeting antibody SC16 (89Zr-DFO-SC16), we have developed a positron emission tomography (PET) agent to non-invasively identify the presence of DLL3-positive NEPC lesions. Deferoxamine delta like canonical Notch ligand 3 Homo sapiens
2 Using the zirconium-89 (89Zr)-labeled DLL3 targeting antibody SC16 (89Zr-DFO-SC16), we have developed a positron emission tomography (PET) agent to non-invasively identify the presence of DLL3-positive NEPC lesions. Deferoxamine delta like canonical Notch ligand 3 Homo sapiens
3 Conclusion: These studies demonstrate H660 NEPC cells selectively express DLL3 on their cell surface and can be non-invasively identified with 89Zr-DFO-SC16. Deferoxamine delta like canonical Notch ligand 3 Homo sapiens