Title : The involvement of ERK1/2 and p38 MAPK in the premature senescence of melanocytes induced by H2O2 through a p53-independent p21 pathway.

Pub. Date : 2022 Feb

PMID : 35042627






1 Functional Relationships(s)
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1 CONCLUSION: H2O2 increases ROS levels, which activates the ERK1/2 and p38 MAPK pathways to induce the premature senescence of melanocytes through p21 via a p53-independent pathway and consequently disrupts melanosome transfer. ros tumor protein p53 Homo sapiens