Title : A γ-glutamyl hydrolase lacking the signal peptide confers susceptibility to folates/antifolates in acute lymphoblastic leukemia cells.

Pub. Date : 2022 Feb

PMID : 35040120






1 Functional Relationships(s)
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1 In this study, we show that intact GGH is not indispensable for the chemosensitivity and growth of acute lymphoblastic leukemia (ALL) cells, whereas GGH lacking N-terminal signal peptide (GGH-DeltaN ) confers the significant drug resistance of ALL cells to the antifolates MTX and RTX. resiniferatoxin gamma-glutamyl hydrolase Homo sapiens