Title : Increased synovial galectin-3 induce inflammatory fibroblast activation and osteoclastogenesis in patients with rheumatoid arthritis.

Pub. Date : 2022 Jan 13

PMID : 35023445






1 Functional Relationships(s)
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1 In vitro, co-incubation with a Gal-3 inhibitor (GB1107, 10 microM) led to a significant reduction in both interleukin-1beta and tumour necrosis factor-alpha secretion from FLS monocultures (both p < 0.05) and decreased monocyte-derived osteoclastogenesis compared with controls (both p < 0.05). GB1107 interleukin 1 beta Homo sapiens