Pub. Date : 2022 Mar 1
PMID : 35020443
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The nuclear localization of TFEB is blocked by the mechanistic target of rapamycin complex 1 (mTORC1)-dependent phosphorylation of TFEB at multiple sites including Ser-211. | Serine | CREB regulated transcription coactivator 1 | Mus musculus |
| 2 | Thus, when PIKfyve is inhibited, PP2A is dominant over mTORC1 for control of TFEB phosphorylation at Ser-S211. | Serine | CREB regulated transcription coactivator 1 | Mus musculus |
| 3 | Together these findings suggest that mTORC1 and PP2A have opposing roles on TFEB via phosphorylation and dephosphorylation of Ser-211, respectively, and further, that PIKfyve inhibits TFEB activity by facilitating mTORC1-dependent phosphorylation of TFEB. | Serine | CREB regulated transcription coactivator 1 | Mus musculus |