Title : Translocator Protein Ligand PIGA1138 Reduces Disease Symptoms and Severity in Experimental Autoimmune Encephalomyelitis Model of Primary Progressive Multiple Sclerosis.

Pub. Date : 2022 Mar

PMID : 35018577






2 Functional Relationships(s)
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1 PIGA1138 (15 mg/kg) drastically reduced MOG-EAE mice clinical scores, ameliorated motor dysfunctions assessed with the Catwalk device, and counteracted MOG-EAE-induced demyelination by preserving Myelin basic protein (MBP) expression in the CNS. piga1138 myelin oligodendrocyte glycoprotein Mus musculus
2 Concordantly, PIGA1138 enhanced anti-inflammatory interleukin-10 serum level in MOG-EAE mice. piga1138 myelin oligodendrocyte glycoprotein Mus musculus