Pub. Date : 2022 Jan
PMID : 35012432
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The protective effects of Olmesartan against interleukin-29 (IL-29)-induced type 2 collagen degradation in human chondrocytes. | olmesartan | interferon lambda 1 | Homo sapiens |
| 2 | The protective effects of Olmesartan against interleukin-29 (IL-29)-induced type 2 collagen degradation in human chondrocytes. | olmesartan | interferon lambda 1 | Homo sapiens |
| 3 | We found that the degradation of type 2 collagens and aggrecans was induced by IL-29, accompanied by the upregulation of MMPs and ADAMTSs, but the presence of Olmesartan significantly ameliorated these increases. | olmesartan | interferon lambda 1 | Homo sapiens |
| 4 | In addition, Olmesartan abolished IL-29- induced oxidative stress and elevated the expression level of TNF receptor-associated factor 6 (TRAF-6). | olmesartan | interferon lambda 1 | Homo sapiens |
| 5 | Collectively, our data reveal that Olmesartan exerted a protective function on IL-29- induced type 2 collagen degradation in human chondrocytes. | olmesartan | interferon lambda 1 | Homo sapiens |