Pub. Date : 2022 Jan
PMID : 35012428
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Based on the network diagram of "traditional Chinese medicine - component - target - disease" and KEGG analysis, quercetin might exhibit certain effects on colon cancer treatment by regulating the biological behavior of core targets related to cell apoptosis in tumors including PIK3R1, PIK3CA, Akt1, and Akt2. | Quercetin | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | Therefore, the activation of PI3K/AKT phosphorylation was inhibited by quercetin and moreover the expressions of apoptotic proteins caspase-3 and Bcl2-Associated X protein (BAX) were up-regulated. | Quercetin | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | In conclusion, the potential mechanism of nightshade lies in the activation of the PI3K/AKT signaling pathway inhibited by quercetin, thus promoting apoptosis of colon cancer cells for colon cancer treatment. | Quercetin | AKT serine/threonine kinase 1 | Homo sapiens |