Title : Expression of the human B-cell surface protein CD20: alteration by phorbol 12-myristate 13-acetate.

Pub. Date : 1987 Nov

PMID : 3500472






5 Functional Relationships(s)
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1 Expression of the human B-cell surface protein CD20: alteration by phorbol 12-myristate 13-acetate. Tetradecanoylphorbol Acetate keratin 20 Homo sapiens
2 Because phorbol 12-myristate 13-acetate (PMA) supports the activation signal initiated by monoclonal antibody 1F5, we studied the effect of PMA on CD20 expression. Tetradecanoylphorbol Acetate keratin 20 Homo sapiens
3 Furthermore, PMA not only induced phosphorylation of CD20 protein on Raji cells but also increased the internalization of CD20 molecules; both phosphorylation and internalization of CD20 molecules were decreased with the protein kinase C inhibitor palmitoyl carnitine. Tetradecanoylphorbol Acetate keratin 20 Homo sapiens
4 Furthermore, PMA not only induced phosphorylation of CD20 protein on Raji cells but also increased the internalization of CD20 molecules; both phosphorylation and internalization of CD20 molecules were decreased with the protein kinase C inhibitor palmitoyl carnitine. Tetradecanoylphorbol Acetate keratin 20 Homo sapiens
5 Furthermore, PMA not only induced phosphorylation of CD20 protein on Raji cells but also increased the internalization of CD20 molecules; both phosphorylation and internalization of CD20 molecules were decreased with the protein kinase C inhibitor palmitoyl carnitine. Tetradecanoylphorbol Acetate keratin 20 Homo sapiens