Title : Endoplasmic reticulum stress-dependent activation of TRB3-FoxO1 signaling pathway exacerbates hyperglycemic nephrotoxicity: Protection accorded by Naringenin.

Pub. Date : 2022 Feb 15

PMID : 34998792






3 Functional Relationships(s)
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1 Endoplasmic reticulum stress-dependent activation of TRB3-FoxO1 signaling pathway exacerbates hyperglycemic nephrotoxicity: Protection accorded by naringenin. naringenin tribbles pseudokinase 3 Rattus norvegicus
2 Treatment with Naringenin reduced the expression of TRB3, an ER stress-inducible pseudokinase, both in vitro and in vivo. naringenin tribbles pseudokinase 3 Rattus norvegicus
3 These findings affirm that activation of TRB3-FoxO1 signaling is critical in the pathogenesis of hyperglycemia-induced renal toxicity and protective effect of Naringenin via modulation of ER stress may be exploited as a novel approach for its management. naringenin tribbles pseudokinase 3 Rattus norvegicus