Title : Effects of tumor-promoting agents 12-O-tetradecanoylphorbol-13-acetate and phenobarbital on DNA synthesis of rat hepatocytes in primary culture.

Pub. Date : 1987 Nov 1

PMID : 3499217






5 Functional Relationships(s)
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1 Both 12-O-tetradecanoylphorbol-13-acetate (TPA) and phenobarbital (PB) enhanced hepatocyte DNA synthesis stimulated with epidermal growth factor (EGF) by 60 to 80% in primary culture when measured by the incorporation of [3H]thymidine. Tetradecanoylphorbol Acetate epidermal growth factor like 1 Rattus norvegicus
2 Both 12-O-tetradecanoylphorbol-13-acetate (TPA) and phenobarbital (PB) enhanced hepatocyte DNA synthesis stimulated with epidermal growth factor (EGF) by 60 to 80% in primary culture when measured by the incorporation of [3H]thymidine. Tetradecanoylphorbol Acetate epidermal growth factor like 1 Rattus norvegicus
3 Both 12-O-tetradecanoylphorbol-13-acetate (TPA) and phenobarbital (PB) enhanced hepatocyte DNA synthesis stimulated with epidermal growth factor (EGF) by 60 to 80% in primary culture when measured by the incorporation of [3H]thymidine. Tetradecanoylphorbol Acetate epidermal growth factor like 1 Rattus norvegicus
4 Both 12-O-tetradecanoylphorbol-13-acetate (TPA) and phenobarbital (PB) enhanced hepatocyte DNA synthesis stimulated with epidermal growth factor (EGF) by 60 to 80% in primary culture when measured by the incorporation of [3H]thymidine. Tetradecanoylphorbol Acetate epidermal growth factor like 1 Rattus norvegicus
5 The binding of EGF was transiently down-regulated by TPA, then restored to control values 6 h later, whereas the binding of this factor was significantly increased at both the 12th and 24th h after PB addition. Tetradecanoylphorbol Acetate epidermal growth factor like 1 Rattus norvegicus