Title : Real-world PM2.5 exposure induces pathological injury and DNA damage associated with miRNAs and DNA methylation alteration in rat lungs.

Pub. Date : 2022 Apr

PMID : 34988794






2 Functional Relationships(s)
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1 Besides, PM2.5 significantly elevated OGG1 expression and suppressed MTH1 expression, which was correlated to oxidative stress and partially mediated by reducing OGG1 DNA methylation status and increasing miRNAs expression related to MTH1 in DNA damage with increases of gamma-H2AX, 8-OHdG and GADD153. gamma-h2ax nudix hydrolase 1 Rattus norvegicus
2 Besides, PM2.5 significantly elevated OGG1 expression and suppressed MTH1 expression, which was correlated to oxidative stress and partially mediated by reducing OGG1 DNA methylation status and increasing miRNAs expression related to MTH1 in DNA damage with increases of gamma-H2AX, 8-OHdG and GADD153. gamma-h2ax nudix hydrolase 1 Rattus norvegicus