Title : DNMT1 regulates the timing of DNA methylation by DNMT3 in an enzymatic activity-dependent manner in mouse embryonic stem cells.

Pub. Date : 2022

PMID : 34986190






1 Functional Relationships(s)
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1 In mouse embryonic stem cells (ESCs), de novo DNAme by DNMT3 family enzymes, demethylation by the TET-mediated conversion of 5mC to 5-hydroxymethylation (5hmC), and maintenance of the remaining DNAme by DNMT1 are actively repeated throughout cell cycles, dynamically forming a constant 5mC profile. 5-Methylcytidine 5'-monophosphate DNA methyltransferase (cytosine-5) 1 Mus musculus