Title : Empagliflozin Ameliorates Ouabain-Induced Na+ and Ca2+ Dysregulations in Ventricular Myocytes in an Na+-Dependent Manner.

Pub. Date : 2022 Jan 4

PMID : 34982348






3 Functional Relationships(s)
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Protein Name
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1 Pretreatment with the Na+/H+ exchanger (NHE) inhibitor (1 mumol/L cariporide) abolished the effects of empagliflozin. empagliflozin solute carrier family 9 member C1 Homo sapiens
2 Pretreatment with the Na+/H+ exchanger (NHE) inhibitor (1 mumol/L cariporide) abolished the effects of empagliflozin. empagliflozin solute carrier family 9 member C1 Homo sapiens
3 CONCLUSION: Empagliflozin ameliorates ouabain-induced Na+ and Ca2+ handling disorders in a cytosolic Na+-dependent manner, potentially by inhibiting the NHE. empagliflozin solute carrier family 9 member C1 Homo sapiens