Title : Combined treatment with dihydrotestosterone and lipopolysaccharide modulates prostate homeostasis by upregulating TNF-α from M1 macrophages and promotes proliferation of prostate stromal cells.

Pub. Date : 2021 Dec 31

PMID : 34975070






3 Functional Relationships(s)
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1 Combined treatment with dihydrotestosterone and lipopolysaccharide modulates prostate homeostasis by upregulating TNF-alpha from M1 macrophages and promotes proliferation of prostate stromal cells. Dihydrotestosterone tumor necrosis factor Homo sapiens
2 We found that DHT increased secretion of the pro-inflammatory factor tumor necrosis factor (TNF)-alpha from M1 macrophages differentiated from THP-1 cells. Dihydrotestosterone tumor necrosis factor Homo sapiens
3 This study suggests that DHT modulates the inflammatory environment of BPH by increasing TNF-alpha expression from lipopolysaccharide-treated M1 macrophages and promotes the proliferation of prostate stromal cells. Dihydrotestosterone tumor necrosis factor Homo sapiens