Title : GPC2-CAR T cells tuned for low antigen density mediate potent activity against neuroblastoma without toxicity.

Pub. Date : 2022 Jan 10

PMID : 34971569






2 Functional Relationships(s)
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1 Iterative engineering of transmembrane (TM) and co-stimulatory domains plus overexpression of c-Jun lowered the GPC2-CAR antigen density threshold, enabling potent and durable eradication of NBs expressing clinically relevant GPC2 antigen density, without toxicity. Niobium glypican 2 Homo sapiens
2 Iterative engineering of transmembrane (TM) and co-stimulatory domains plus overexpression of c-Jun lowered the GPC2-CAR antigen density threshold, enabling potent and durable eradication of NBs expressing clinically relevant GPC2 antigen density, without toxicity. Niobium glypican 2 Homo sapiens