Title : Mulberry Leaf Polyphenol Extract and Rutin Induces Autophagy Regulated by p53 in Human Hepatoma HepG2 Cells.

Pub. Date : 2021 Dec 15

PMID : 34959709






3 Functional Relationships(s)
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1 Moreover, treatment with the p53 inhibitor pifithrin-alpha (PFT-alpha) inhibited autophagy and increased apoptotic response in MLPE-treated HepG2 cells. pifithrin tumor protein p53 Homo sapiens
2 Moreover, treatment with the p53 inhibitor pifithrin-alpha (PFT-alpha) inhibited autophagy and increased apoptotic response in MLPE-treated HepG2 cells. pifithrin tumor protein p53 Homo sapiens
3 Thus, co-treatment with MLPE and PFT-alpha significantly increased caspase-3, caspase-8, and cytochrome c release, indicating that p53 deficiency caused the apoptosis. pifithrin tumor protein p53 Homo sapiens