Title : Inhibition of EZH2 ameliorates hyperoxaluria-induced kidney injury through the JNK/FoxO3a pathway.

Pub. Date : 2022 Feb 15

PMID : 34952043






3 Functional Relationships(s)
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1 The 3-DZNeP, a selective EZH2 inhibitor, was administered in vivo and in vitro. 3-dznep enhancer of zeste 2 polycomb repressive complex 2 subunit Rattus norvegicus
2 KEY FINDINGS: Inhibition of EZH2 by 3-DZNeP significantly attenuated hyperoxaluria-induced oxidative and inflammatory injury and CaOx crystal deposition in vivo. 3-dznep enhancer of zeste 2 polycomb repressive complex 2 subunit Rattus norvegicus
3 EZH2 inhibition using 3-DZNeP blocked these effects. 3-dznep enhancer of zeste 2 polycomb repressive complex 2 subunit Rattus norvegicus