Pub. Date : 2021 Dec 11
PMID : 34948122
1 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Since the BIN1 gene rarely mutates in human cancers, our results suggest that simultaneous inhibition of PARP1 and ATM provokes a new BRCAness-independent synthetic lethal effect and ultimately re-establishes cisplatin sensitivity even in platinum-refractory cancer cells. | Platinum | ATM serine/threonine kinase | Homo sapiens |