Title : DFMO Improves Survival and Increases Immune Cell Infiltration in Association with MYC Downregulation in the Pancreatic Tumor Microenvironment.

Pub. Date : 2021 Dec 7

PMID : 34947972






5 Functional Relationships(s)
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1 DFMO Improves Survival and Increases Immune Cell Infiltration in Association with MYC Downregulation in the Pancreatic Tumor Microenvironment. Eflornithine myelocytomatosis oncogene Mus musculus
2 Here, we targeted KRAS, through inhibition of downstream c-RAF with GW5074, and MYC expression via difluoromethylornithine (DFMO). Eflornithine myelocytomatosis oncogene Mus musculus
3 Here, we targeted KRAS, through inhibition of downstream c-RAF with GW5074, and MYC expression via difluoromethylornithine (DFMO). Eflornithine myelocytomatosis oncogene Mus musculus
4 To further investigate, immunohistochemical staining showed DFMO diminished MYC expression and increased tumor infiltration of macrophages, CD86+ cells, CD4+ and CD8+ T lymphocytes. Eflornithine myelocytomatosis oncogene Mus musculus
5 Collectively, this study highlights that in contrast to GW5074, the inhibition of MYC through DFMO may be an effective treatment modality to modulate PDAC immunosuppression. Eflornithine myelocytomatosis oncogene Mus musculus