CPRiL

5 Functional Relationships(s) Download
	Sentence	Compound Name	Protein Name	Organism
1	Using competitive binding experiments between Ca2+ and Zn2+ and QM/MM molecular modeling we conclude that Zn2+ high affinity sites are located in the EF-hand motifs of S100A1.	Zinc	carbonic anhydrase 2	Homo sapiens
2	Using competitive binding experiments between Ca2+ and Zn2+ and QM/MM molecular modeling we conclude that Zn2+ high affinity sites are located in the EF-hand motifs of S100A1.	Zinc	carbonic anhydrase 2	Homo sapiens
3	In addition, two lower affinity sites can bind Zn2+ even when the EF-hands are saturated by Ca2+, resulting in a 2Ca2+:S100A1:2Zn2+ conformer.	Zinc	carbonic anhydrase 2	Homo sapiens
4	We also determined a higher affinity to Ca2+ (KD~0.16 and 24 mum) than was previously reported for S100A1, which would allow this protein to function as a Ca2+/Zn2+-sensor both inside and outside cells, participating in diverse signaling pathways under normal and pathological conditions.	Zinc	carbonic anhydrase 2	Homo sapiens
5	We also determined a higher affinity to Ca2+ (KD~0.16 and 24 mum) than was previously reported for S100A1, which would allow this protein to function as a Ca2+/Zn2+-sensor both inside and outside cells, participating in diverse signaling pathways under normal and pathological conditions.	Zinc	carbonic anhydrase 2	Homo sapiens