Pub. Date : 2022 Apr 26
PMID : 34935917
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We found that the umbilical vein constriction induced by ACh in the IVF-ET group was significantly attenuated compared with that in the healthy normal pregnancy group, which was not only associated with the hypermethylation of ACh muscarinic receptor subtype 3 (CHRM3) and decreased expression of CHRM3, PKCbeta and CaV1.2, but was also related to the reduced phosphorylation of MLC20. | Acetylcholine | cholinergic receptor muscarinic 3 | Homo sapiens |
| 2 | We found that the umbilical vein constriction induced by ACh in the IVF-ET group was significantly attenuated compared with that in the healthy normal pregnancy group, which was not only associated with the hypermethylation of ACh muscarinic receptor subtype 3 (CHRM3) and decreased expression of CHRM3, PKCbeta and CaV1.2, but was also related to the reduced phosphorylation of MLC20. | Acetylcholine | cholinergic receptor muscarinic 3 | Homo sapiens |
| 3 | We found that the umbilical vein constriction induced by ACh in the IVF-ET group was significantly attenuated compared with that in the healthy normal pregnancy group, which was not only associated with the hypermethylation of ACh muscarinic receptor subtype 3 (CHRM3) and decreased expression of CHRM3, PKCbeta and CaV1.2, but was also related to the reduced phosphorylation of MLC20. | Acetylcholine | cholinergic receptor muscarinic 3 | Homo sapiens |
| 4 | The present study revealed that the hypermethylation of CHRM3, leading to a reduction in CHRM3 expression and downregulation of the CaV1.2/PKC-MLC20 phosphorylation pathway, was responsible for the decreased sensitivity to ACh observed in the umbilical vein under IVF-ET conditions. | Acetylcholine | cholinergic receptor muscarinic 3 | Homo sapiens |
| 5 | The present study revealed that the hypermethylation of CHRM3, leading to a reduction in CHRM3 expression and downregulation of the CaV1.2/PKC-MLC20 phosphorylation pathway, was responsible for the decreased sensitivity to ACh observed in the umbilical vein under IVF-ET conditions. | Acetylcholine | cholinergic receptor muscarinic 3 | Homo sapiens |