Pub. Date : 2022 Feb
PMID : 34935059
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Berberine enhances gemcitabine-induced cytotoxicity in bladder cancer by downregulating Rad51 expression through inactivating the PI3K/Akt pathway. | Berberine | RAD51 recombinase | Homo sapiens |
| 2 | BER enhanced GEM-induced cytotoxicity, apoptosis and inhibition of migration, whilst attenuating the GEM-induced upregulation of phosphorylated Akt and Rad51 expression. | Berberine | RAD51 recombinase | Homo sapiens |
| 3 | Knockdown of Rad51 enhanced GEM-induced cytotoxicity, whilst overexpression of Rad51 reversed the suppressed cell viability induced by BER and GEM. | Berberine | RAD51 recombinase | Homo sapiens |
| 4 | Knockdown of Rad51 enhanced GEM-induced cytotoxicity, whilst overexpression of Rad51 reversed the suppressed cell viability induced by BER and GEM. | Berberine | RAD51 recombinase | Homo sapiens |
| 5 | Inactivation of the PI3K/Akt pathway by LY294002 or BER enhanced GEM-induced cytotoxicity and downregulated Rad51 expression, whilst overexpression of constitutively active Akt restored Rad51 expression and cell viability that was previously decreased by BER and GEM. | Berberine | RAD51 recombinase | Homo sapiens |
| 6 | Inactivation of the PI3K/Akt pathway by LY294002 or BER enhanced GEM-induced cytotoxicity and downregulated Rad51 expression, whilst overexpression of constitutively active Akt restored Rad51 expression and cell viability that was previously decreased by BER and GEM. | Berberine | RAD51 recombinase | Homo sapiens |