Title : The fatty acid site is coupled to functional motifs in the SARS-CoV-2 spike protein and modulates spike allosteric behaviour.

Pub. Date : 2021 Dec 11

PMID : 34934478






2 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 The presence of linoleic acid at this site modulates binding of the spike to the human ACE2 receptor, stabilizing a locked conformation of the protein. Linoleic Acid surface glycoprotein Severe acute respiratory syndrome coronavirus 2
2 These communication networks significantly involve positions that are prone to mutation, indicating that observed genetic variation in the spike may alter its response to linoleate binding and associated allosteric communication. Linoleic Acid surface glycoprotein Severe acute respiratory syndrome coronavirus 2