Title : DZNep promotes mouse bone defect healing via enhancing both osteogenesis and osteoclastogenesis.

Pub. Date : 2021 Dec 20

PMID : 34930462






1 Functional Relationships(s)
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1 Furthermore, we identified that DZNep promoted the receptor activator of nuclear factor-kappaB (NF-kappaB) ligand (RANKL)-induced osteoclast formation via facilitating the phosphorylation of IKKalpha/beta, IkappaB, and subsequently NF-kappaB nuclear translocation, which credit to the EZH2-H3K27me3-Foxc1 axis. 3-deazaneplanocin conserved helix-loop-helix ubiquitous kinase Mus musculus