Title : NMNAT promotes glioma growth through regulating post-translational modifications of P53 to inhibit apoptosis.

Pub. Date : 2021 Dec 17

PMID : 34919052






3 Functional Relationships(s)
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1 Mechanistic analysis suggests that NMNAT interferes with DNA damage-p53-caspase-3 apoptosis signaling pathway by enhancing NAD+-dependent posttranslational modifications (PTMs) poly(ADP-ribosyl)ation (PARylation) and deacetylation of p53. NAD tumor protein p53 Homo sapiens
2 Our findings reveal a novel tumorigenic mechanism involving protein complex formation of p53 with NAD+ synthetic enzyme NMNAT and NAD+-dependent PTM enzymes that regulates glioma growth. NAD tumor protein p53 Homo sapiens
3 Our findings reveal a novel tumorigenic mechanism involving protein complex formation of p53 with NAD+ synthetic enzyme NMNAT and NAD+-dependent PTM enzymes that regulates glioma growth. NAD tumor protein p53 Homo sapiens