Title : Bisphenol A drives di(2-ethylhexyl) phthalate promoting thyroid tumorigenesis via regulating HDAC6/PTEN and c-MYC signaling.

Pub. Date : 2022 Mar 5

PMID : 34910997






1 Functional Relationships(s)
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1 Mechanistically, BPA alone and in combination with MEHP could significantly induce the proliferation of BCPAP cells depending on HDAC6, which could modulate H3K9ac to inhibit PTEN, activate AKT signaling pathway, and simultaneously upregulate the expression of c-MYC. mono-(2-ethylhexyl)phthalate AKT serine/threonine kinase 1 Homo sapiens