Pub. Date : 2021 Dec
PMID : 34903884
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | NADH inhibition of SIRT1 links energy state to transcription during time-restricted feeding. | NAD | sirtuin 1 | Mus musculus |
| 2 | In mammals, circadian rhythms are entrained to the light cycle and drive daily oscillations in levels of NAD+, a cosubstrate of the class III histone deacetylase sirtuin 1 (SIRT1) that associates with clock transcription factors. | NAD | sirtuin 1 | Mus musculus |
| 3 | In mammals, circadian rhythms are entrained to the light cycle and drive daily oscillations in levels of NAD+, a cosubstrate of the class III histone deacetylase sirtuin 1 (SIRT1) that associates with clock transcription factors. | NAD | sirtuin 1 | Mus musculus |
| 4 | Enzymatic analyses reveal that NADH inhibits SIRT1 in vitro, corresponding with reduced deacetylation of SIRT1 substrates during TRF-CR in vivo. | NAD | sirtuin 1 | Mus musculus |
| 5 | Enzymatic analyses reveal that NADH inhibits SIRT1 in vitro, corresponding with reduced deacetylation of SIRT1 substrates during TRF-CR in vivo. | NAD | sirtuin 1 | Mus musculus |
| 6 | Our findings reveal that the hepatic NADH cycle links nutrient state to whole-body energetics through the rhythmic regulation of SIRT1. | NAD | sirtuin 1 | Mus musculus |