Title : NADH inhibition of SIRT1 links energy state to transcription during time-restricted feeding.

Pub. Date : 2021 Dec

PMID : 34903884






6 Functional Relationships(s)
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1 NADH inhibition of SIRT1 links energy state to transcription during time-restricted feeding. NAD sirtuin 1 Mus musculus
2 In mammals, circadian rhythms are entrained to the light cycle and drive daily oscillations in levels of NAD+, a cosubstrate of the class III histone deacetylase sirtuin 1 (SIRT1) that associates with clock transcription factors. NAD sirtuin 1 Mus musculus
3 In mammals, circadian rhythms are entrained to the light cycle and drive daily oscillations in levels of NAD+, a cosubstrate of the class III histone deacetylase sirtuin 1 (SIRT1) that associates with clock transcription factors. NAD sirtuin 1 Mus musculus
4 Enzymatic analyses reveal that NADH inhibits SIRT1 in vitro, corresponding with reduced deacetylation of SIRT1 substrates during TRF-CR in vivo. NAD sirtuin 1 Mus musculus
5 Enzymatic analyses reveal that NADH inhibits SIRT1 in vitro, corresponding with reduced deacetylation of SIRT1 substrates during TRF-CR in vivo. NAD sirtuin 1 Mus musculus
6 Our findings reveal that the hepatic NADH cycle links nutrient state to whole-body energetics through the rhythmic regulation of SIRT1. NAD sirtuin 1 Mus musculus