Title : Targeting Chemotherapy to Decondensed H3K27me3-Marked Chromatin of AML Cells Enhances Leukemia Suppression.

Pub. Date : 2022 Feb 1

PMID : 34903608






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 In the p53-null KG-1 and THP-1 AML cell lines, EZH2 inhibitor and doxorubicin co-treatment induced transcriptional reprogramming that was, in part, dependent on de-repression of H3K27me3-marked gene promoters and led to increased expression of cell death-promoting and growth-inhibitory genes. Doxorubicin tumor protein p53 Homo sapiens