Title : Prodigiosin inhibits cholangiocarcinoma cell proliferation and induces apoptosis via suppressing SNAREs-dependent autophagy.

Pub. Date : 2021 Dec 9

PMID : 34886869






2 Functional Relationships(s)
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1 Mechanistically, PG inhibits the fusion of autophagosomes and lysosomes by blocking STX17 and SNAP29, components of soluble N-ethyl-maleimide-sensitive factor attachment protein receptors (SNAREs)complex. Prodigiosin synaptosomal-associated protein 29 Mus musculus
2 When STX17 and SNAP29 were overexpressed, the inhibitory effect of PG on CCA cells autophagy was relieved. Prodigiosin synaptosomal-associated protein 29 Mus musculus