Title : Small Molecule CD38 Inhibitors: Synthesis of 8-Amino-N1-inosine 5'-monophosphate, Analogues and Early Structure-Activity Relationship.

Pub. Date : 2021 Nov 26

PMID : 34885748






1 Functional Relationships(s)
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1 Although a monoclonal antibody targeting the multifunctional ectoenzyme CD38 is an FDA-approved drug, few small molecule inhibitors exist for this enzyme that catalyzes inter alia the formation and metabolism of the N1-ribosylated, Ca2+-mobilizing, second messenger cyclic adenosine 5"-diphosphoribose (cADPR). Adenosine CD38 molecule Homo sapiens