Pub. Date : 2022 Jan
PMID : 34882521
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Circ_0073748 was upregulated and miR-132-3p was downregulated in AP patients" plasma and human pancreatic ductal HPDE6-C7 cells with caerulein induction. | Ceruletide | microRNA 1323 | Homo sapiens |
| 2 | Interfering circ_0073748 and reinforcing miR-132-3p improved cell viability, EdU incorporation, and superoxide dismutase (SOD) activity of caerulein-treated HPDE6-C7 cells but suppressed malonaldehyde (MDA), IL-6 and TNF-alpha levels and apoptosis rate. | Ceruletide | microRNA 1323 | Homo sapiens |
| 3 | Moreover, TRAF3 downregulation was allied with circ_0073748 silencing and miR-132-3p overexpression in caerulein-induced HPDE6-C7 cells. | Ceruletide | microRNA 1323 | Homo sapiens |
| 4 | Notably, circ_0073748 blockage could suppress expressions of phosphorylated P65 (p-P65) and p-IkappaB in caerulein-induced HPDE6-C7 cells by promoting miR-132-3p and inhibiting TRAF3. | Ceruletide | microRNA 1323 | Homo sapiens |
| 5 | Silencing circ_0073748 and upregulating miR-132-3p could alleviate caerulein-induced HPDE6-C7 injury and inactivate canonical NF-kappaB signal by inhibiting TRAF3. | Ceruletide | microRNA 1323 | Homo sapiens |
| 6 | Circ_0073748/miR-132-3p/TRAF3 ceRNA pathway might be one underlying mechanism and therapeutic target of caerulein-induced AP. | Ceruletide | microRNA 1323 | Homo sapiens |