Title : P-gp expression inhibition mediates placental glucocorticoid barrier opening and fetal weight loss.

Pub. Date : 2021 Dec 8

PMID : 34876109






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Combined with the PCE-induced IUGR rat model, in vitro caffeine-treated placental trophoblasts, we confirmed that caffeine decreased the histone acetylation and expression of P-gp via RYR/JNK/YB-1/P300 pathway, which inhibited placental and fetal development. Caffeine ryanodine receptor 2 Rattus norvegicus